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Again, start with the question of what suits your needs best. A duffel style is roomy and casual, and conveys a sporty appearance. If you don't have a lot of clothes that need ironing or special care, or if you want to maximize every inch of space, consider a carry-on duffel.
Perhaps you want to keep it simple and just have a tote on board that includes the essentials—maybe some snacks (non-liquid, of course), over-the-counter and/or prescription medicines, toothbrush and toothpaste, one day's worth of clothing, camera and any valuables. You can move swiftly and it's hassle-free getting through security.
Wheels are another option, making a carry-on bag of any style easier to manage through a large airport or on a quick connection. Shoulder bags keep your hands free for the important things, such as talking on your cell phone as you walk toward the gate. They can be small, counting as a personal item, or larger to serve as a carry-on.