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If it's been a few years since you used your luggage locks, be aware that you need to get new ones. The Transportation Security Agency has the right to open any bag, and there are special TSA-approved locks that can be opened by authorized agents. If your bag has a non-TSA approved lock, agents are allowed to cut the lock off. If you buy new luggage with locks, they will be TSA-approved, or you can purchase combination locks independently to put on your existing bags.
If you'd rather avoid the lock issue, airport shrink-wrapping services and luggage seals may also be helpful in preventing theft and tampering.